Effect of High‐Dose Acyclovir on Survival in Allogeneic Marrow Transplant Recipients Who Received Ganciclovir at Engraftment or for Cytomegalovirus pp65 Antigenemia
نویسندگان
چکیده
منابع مشابه
Effect of high-dose acyclovir on survival in allogeneic marrow transplant recipients who received ganciclovir at engraftment or for cytomegalovirus pp65 antigenemia.
This study sought to determine whether high-dose acyclovir improves posttransplant survival in cytomegalovirus (CMV)-seropositive patients when ganciclovir is given for prophylaxis or as early therapy. Three groups were studied: Group 1 (n = 112) received ganciclovir from engraftment without prior acyclovir treatment, group 2 (n = 114) was given ganciclovir for CMV pp65 antigenemia without prio...
متن کاملSuccessful modification of a pp65 antigenemia-based early treatment strategy for prevention of cytomegalovirus disease in allogeneic marrow transplant recipients.
We have previously reported that an intermittent pp65 antigenemiaguided early treatment strategy based on quantitative antigenemia was less effective in preventing cytomegalovirus (CMV) disease before day 100 than ganciclovir administered from engraftment until day 100 (ie, 14.1% v 2.7%, P 5 .002).1 We hypothesized that the high incidence of CMV disease before day 100 in the antigenemia-gancicl...
متن کاملCytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study.
To determine whether cytomegalovirus (CMV) antigenemiaguided ganciclovir treatment may be as effective, may require less treatment, and thus may cause less marrow toxicity than ganciclovir administered at engraftment, 226 marrow transplant recipients were randomized at engraftment to receive placebo (antigenemia-ganciclovir group) or ganciclovir (ganciclovir group) until day 100 in a double-bli...
متن کاملGuidance of ganciclovir therapy with pp65 antigenemia in cytomegalovirus-free recipients of livers from seropositive donors.
Cytomegalovirus (CMV*), the first reported transplantassociated opportunistic virus (1), has remained the most frequent single cause or co-cause ofinfections throughout the ensuing three decades (2). Because prophylactic drug and hyperimmune globulin therapy has not been effective in these CMV-infected patients (2-4), Rubin (5) suggested withholding treatment until the phase of rapid viral repl...
متن کاملLack of emergence of cytomegalovirus UL97 mutations conferring ganciclovir (GCV) resistance following preemptive GCV therapy in allogeneic stem cell transplant recipients.
Fifty allogeneic stem cell transplant recipients were enrolled in a prospective cytomegalovirus pp65 antigenemia-guided preemptive therapy trial. Among these, 10 of 34 patients who received ganciclovir exhibited sustained and/or recurrent antigenemia despite treatment. Thirteen leukocyte preparations from these 10 subjects were screened for the presence of the most frequent cytomegalovirus UL97...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 1998
ISSN: 0022-1899,1537-6613
DOI: 10.1086/515673